Restoration of Sarco/Endoplasmic Reticulum Ca2+-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca2+ Depletion

Restoration of Sarco/Endoplasmic Reticulum Ca2+-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca2+ Depletion

Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2+) from cytosol into the lumen of the endoplasmic...

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Bibliographic Details
Main Authors: Wen Zhang, Fanghua Ye, Nan Pang, Miriam Kessi, Juan Xiong, Shimeng Chen, Jing Peng, Li Yang, Fei Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
SERCA2b
excitotoxicity
calcium depletion
endoplasmic reticulum stress
mitochondria
CDN1163
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.877175/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.877175/full

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