Structural and biosynthetic studies of a principal bile alcohol, 27-nor-5β-cholestane-3α,7α,12α,24,25-pentol, in human urine

Structural and biosynthetic studies of a principal bile alcohol, 27-nor-5β-cholestane-3α,7α,12α,24,25-pentol, in human urine

The stereochemistry at C-24 and C-25 of 27-nor-5β-cholestane-3α,7α,12α,24,25-pentol, a principal bile alcohol in human urine, and its biosynthesis are studied. Four stereoisomers of the C26-24,25-pentols were synthesized by reduction with LiAlH4 of the corresponding epoxides prepared from (24S)- or...

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Bibliographic Details
Main Authors: Mizuho Une, Shinji Takenaka, Taiju Kuramoto, Kingo Fujimura, Takahiko Hoshita, Kenji Kihira
Format: Article
Language:English
Published: Elsevier 2000-10-01
Series:Journal of Lipid Research
Subjects:
bile alcohol
bile acid
absolute configuration
human urine
cholesterol
biosynthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752031988X

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http://www.sciencedirect.com/science/article/pii/S002222752031988X

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