Sodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats

Sodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats

Preeclampsia is a maternal hypertension disorder associated with vascular dysfunction and fetal and placental growth restrictions. Placental ischemia is suggested as the primary trigger of preeclampsia-associated impairments of both endothelium-derived nitric oxide (NO) and the vascular activity of...

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Bibliographic Details
Main Authors: Laisla Zanetoni Martins, Maria Luiza Santos da Silva, Serginara David Rodrigues, Sáskia Estela Biasotti Gomes, Laura Molezini, Elen Rizzi, Marcelo Freitas Montenegro, Carlos Alan Dias-Junior
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
preeclampsia
metalloproteinase-2
nitric oxide
sodium nitrite
placental ischemia
Online Access:https://www.mdpi.com/1422-0067/24/16/12818

Internet

https://www.mdpi.com/1422-0067/24/16/12818

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