Engineering In Vitro Organ‐Structured Tumor Model for Evaluating Neoantigen‐Specific T Cell Responses in Hepatocellular Carcinoma

Engineering In Vitro Organ‐Structured Tumor Model for Evaluating Neoantigen‐Specific T Cell Responses in Hepatocellular Carcinoma

Abstract Neoantigens derived from somatic mutations in cancer cells can induce antigen‐specific T‐cell immune response for cancer immunotherapy. However, the 3D models for assessing neoepitope immunogenicity and efficacy of anti‐tumor T‐cell immune response to neoantigens are less than perfect. Here...

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Bibliographic Details
Main Authors: Jingyu Xiao, Fei Wang, Xiaoyan Hu, Dongli Li, Geng Liu, Qumiao Xu, Chao Chen, Haitao Xiang, Xuan Dong, Linnan Zhu, Dishuang Yang, Yanan Gao, Meijuan Wang, Yonglun Luo, Cheng‐Chi Chao, Guanglei Li, Qiongyu Guo
Format: Article
Language:English
Published: Wiley-VCH 2023-08-01
Series:Advanced Materials Interfaces
Subjects:
cancer immunotherapy
hepatocellular carcinoma
minigene modified HepG2 cells
neoantigens
recellularized liver matrix
Online Access:https://doi.org/10.1002/admi.202300155

Internet

https://doi.org/10.1002/admi.202300155

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