A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model

The pathophysiology of extensive cortical tissue destruction observed in hemispheric hypodensity, a severe type of brain injury observed in young children, is unknown. Here, we utilize our unique, large animal model of hemispheric hypodensity with multifactorial injuries and insults to understand th...

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Bibliographic Details
Main Authors: Beth Costine-Bartell, George Price, John Shen, Declan McGuone, Kevin Staley, Ann-Christine Duhaime
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000838