Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes Ovarian Cancer Cell Stemness and Malignancy Through the Notch3-Mediated Signaling

Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes Ovarian Cancer Cell Stemness and Malignancy Through the Notch3-Mediated Signaling

As a significant component in ovarian cancer microenvironment, cancer-associated fibroblasts (CAFs) contribute to cancer progression through interaction with cancer cells. Recent studies demonstrate that interleukin-8 (IL-8) is overexpressed in multiple cancer types and is essential for tumor develo...

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Bibliographic Details
Main Authors: Zhaodong Ji, Wenjuan Tian, Wen Gao, Rongyu Zang, Huaying Wang, Gong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
IL-8
tumor stemness
epithelial ovarian cancer
cancer-associated ovarian fibroblasts
Notch3 signal pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.684505/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.684505/full

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