Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis

Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis

Memory impairment is one of the disabling manifestations of multiple sclerosis (MS) possibly present from the early stages of the disease and for which there is no specific treatment. Hippocampal synaptic dysfunction and dendritic loss, associated with microglial activation, can underlie memory defi...

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Bibliographic Details
Main Authors: Julien Bourel, Vincent Planche, Nadège Dubourdieu, Aymeric Oliveira, Alexandra Séré, Eva-Gunnel Ducourneau, Marion Tible, Marlène Maitre, Thierry Lesté-Lasserre, Agnes Nadjar, Aline Desmedt, Philippe Ciofi, Stéphane H. Oliet, Aude Panatier, Thomas Tourdias
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Neurobiology of Disease
Subjects:
Multiple sclerosis
Memory deficit
hippocampus
Neurodegeneration
Complement
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121002825

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http://www.sciencedirect.com/science/article/pii/S0969996121002825

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