Resistance to antibody–drug conjugates: A review

Resistance to antibody–drug conjugates: A review

Antibody–drug conjugates (ADCs) are antitumor drugs composed of monoclonal antibodies and cytotoxic payload covalently coupled by a linker. Currently, 15 ADCs have been clinically approved worldwide. More than 100 clinical trials at different phases are underway to investigate the newly developed AD...

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Bibliographic Details
Main Authors: Sijia Li, Xinyu Zhao, Kai Fu, Shuangli Zhu, Can Pan, Chuan Yang, Fang Wang, Kenneth K.W. To, Liwu Fu
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Antibody–drug conjugates
Drug resistance
Combination therapy
Targeted therapy
Cytotoxic therapy
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004933

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http://www.sciencedirect.com/science/article/pii/S2211383524004933

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