Luteoloside Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration

Luteoloside Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration

Intervertebral disk degeneration (IDD) is the major cause of low back pain (LBP), which affects 80% of the world’s population. Interleukin 1 beta (IL-1β) is a major inflammatory factor that accelerates disk degeneration, and IL-1β levels increase in degenerative disks. It has recently been reported...

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Bibliographic Details
Main Authors: Jialiang Lin, Jiaoxiang Chen, Zengjie Zhang, Tianzhen Xu, Zhenxuan Shao, Xiaobin Wang, Yuanzhe Ding, Naifeng Tian, Haiming Jin, Sunren Sheng, Weiyang Gao, Yan Lin, Xiaolei Zhang, Xiangyang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
intervertebral disk degeneration
luteoloside
apoptosis
Nrf2
inflammation
nucleus pulposus cell
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00868/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00868/full

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