The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites

The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites

Magnetic resonance imaging-guided focused ultrasound combined with microbubbles injected in the bloodstream (MRIgFUS) temporarily increases the permeability of the blood-brain barrier (BBB), which facilitates the entry of intravenously administered adeno-associated viruses (AAVs) from the blood to t...

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Bibliographic Details
Main Authors: Rikke Hahn Kofoed, Kate Noseworthy, Kathleen Wu, Shuruthisai Sivadas, Lisa Stanek, Bradford Elmer, Kullervo Hynynen, Lamya S. Shihabuddin, Isabelle Aubert
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
focused ultrasound
microbubbles
adeno-associated virus
AAV2-HBKO
blood-brain barrier
gene delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012200136X

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http://www.sciencedirect.com/science/article/pii/S232905012200136X

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