IMB2026791, a Xanthone, Stimulates Cholesterol Efflux by Increasing the Binding of Apolipoprotein A-I to ATP-Binding Cassette Transporter A1

IMB2026791, a Xanthone, Stimulates Cholesterol Efflux by Increasing the Binding of Apolipoprotein A-I to ATP-Binding Cassette Transporter A1

It is known that the ATP-binding cassette transporter A1 (ABCA1) plays a major role in cholesterol homeostasis and high density lipoprotein (HDL) metabolism. Several laboratories have demonstrated that ABCA1 binding to lipid-poor apolipoprotein A-I (apoA-I) will mediate the assembly of nascent HDL a...

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Bibliographic Details
Main Authors: Zijian Xie, Bin Hong, Zhuorong Li, Wei Jiang, Tingting Feng, Yanni Xu, Zhongbing Zhang, Jikai Liu, Shuyi Si
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:Molecules
Subjects:
ABCA1
regulator
high-throughput screening
xanthone
anti-atherosclerosis agent
cholesterol efflux
Online Access:http://www.mdpi.com/1420-3049/17/3/2833/

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http://www.mdpi.com/1420-3049/17/3/2833/

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