Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, th...

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Bibliographic Details
Main Authors: Adolfo Marican, Fabián Avila-Salas, Oscar Valdés, Sergio Wehinger, Jorge Villaseñor, Natalia Fuentealba, Mauricio Arenas-Salinas, Yerko Argandoña, Verónica Carrasco-Sánchez, Esteban F. Durán-Lara
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Pharmaceutics
Subjects:
drug delivery
crosslinking
prednisone
cyclodextrins
swelling
accumulative release
thermogravimetric analysis
Online Access:http://www.mdpi.com/1999-4923/10/1/30

Internet

http://www.mdpi.com/1999-4923/10/1/30

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