Activation of Anti-SARS-CoV-2 Human CTLs by Extracellular Vesicles Engineered with the N Viral Protein

Activation of Anti-SARS-CoV-2 Human CTLs by Extracellular Vesicles Engineered with the N Viral Protein

We propose an innovative anti-SARS-CoV-2 immune strategy based on extracellular vesicles (EVs) inducing an anti-SARS-CoV-2 N CD8<sup>+</sup> T cytotoxic lymphocyte (CTL) immune response. We previously reported that the SARS-CoV-2 N protein can be uploaded at high levels in EVs upon fusio...

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Bibliographic Details
Main Authors: Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Massimo Sanchez, Maurizio Federico
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Vaccines
Subjects:
extracellular vesicles
SARS-CoV-2
CTL immunity
HIV-1 Nef
CD107a
Online Access:https://www.mdpi.com/2076-393X/10/7/1060

Internet

https://www.mdpi.com/2076-393X/10/7/1060

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