New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project
As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity,...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Toxicology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2024.1339104/full |
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| author | Igor Snapkow Nicola M. Smith Emma Arnesdotter Karsten Beekmann Etienne B. Blanc Albert Braeuning Emanuela Corsini Marija Sollner Dolenc Loes P. M. Duivenvoorde Gunnar Sundstøl Eriksen Nina Franko Valentina Galbiati Johanna M. Gostner Nathalie Grova Arno C. Gutleb Rita Hargitai Aafke W. F. Janssen Solveig A. Krapf Birgitte Lindeman Katalin Lumniczky Ambra Maddalon Steen Mollerup Lucia Parráková Arkadiusz Pierzchalski Raymond H. H. Pieters Raymond H. H. Pieters Maria J. Silva Anita Solhaug Yvonne C. M. Staal Anne Straumfors Tünde Szatmári Jonathan D. Turner Rob J. Vandebriel Ana Claudia Zenclussen Robert Barouki |
| author_facet | Igor Snapkow Nicola M. Smith Emma Arnesdotter Karsten Beekmann Etienne B. Blanc Albert Braeuning Emanuela Corsini Marija Sollner Dolenc Loes P. M. Duivenvoorde Gunnar Sundstøl Eriksen Nina Franko Valentina Galbiati Johanna M. Gostner Nathalie Grova Arno C. Gutleb Rita Hargitai Aafke W. F. Janssen Solveig A. Krapf Birgitte Lindeman Katalin Lumniczky Ambra Maddalon Steen Mollerup Lucia Parráková Arkadiusz Pierzchalski Raymond H. H. Pieters Raymond H. H. Pieters Maria J. Silva Anita Solhaug Yvonne C. M. Staal Anne Straumfors Tünde Szatmári Jonathan D. Turner Rob J. Vandebriel Ana Claudia Zenclussen Robert Barouki |
| author_sort | Igor Snapkow |
| collection | DOAJ |
| description | As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immunotoxicity of chemicals relies heavily on rodent models and a limited number of Organisation for Economic Co-operation and Development (OECD) test guidelines, which only capture a fraction of potential toxic properties. Due to this limitation, various authorities, including the World Health Organization and the European Food Safety Authority have highlighted the need for the development of novel approaches without the use of animals for immunotoxicity testing of chemicals. In this paper, we present a concise overview of ongoing efforts dedicated to developing and standardizing methodologies for a comprehensive characterization of the immunotoxic effects of chemicals, which are performed under the EU-funded Partnership for the Assessment of Risk from Chemicals (PARC). |
| first_indexed | 2024-04-24T11:55:12Z |
| format | Article |
| id | doaj.art-27a61a2796534e779b630318da5896bf |
| institution | Directory Open Access Journal |
| issn | 2673-3080 |
| language | English |
| last_indexed | 2024-04-24T11:55:12Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj.art-27a61a2796534e779b630318da5896bf2024-04-09T04:25:44ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802024-04-01610.3389/ftox.2024.13391041339104New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) projectIgor Snapkow0Nicola M. Smith1Emma Arnesdotter2Karsten Beekmann3Etienne B. Blanc4Albert Braeuning5Emanuela Corsini6Marija Sollner Dolenc7Loes P. M. Duivenvoorde8Gunnar Sundstøl Eriksen9Nina Franko10Valentina Galbiati11Johanna M. Gostner12Nathalie Grova13Arno C. Gutleb14Rita Hargitai15Aafke W. F. Janssen16Solveig A. Krapf17Birgitte Lindeman18Katalin Lumniczky19Ambra Maddalon20Steen Mollerup21Lucia Parráková22Arkadiusz Pierzchalski23Raymond H. H. Pieters24Raymond H. H. Pieters25Maria J. Silva26Anita Solhaug27Yvonne C. M. Staal28Anne Straumfors29Tünde Szatmári30Jonathan D. Turner31Rob J. Vandebriel32Ana Claudia Zenclussen33Robert Barouki34Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, NorwayLuxembourg Institute of Science and Technology (LIST), Belvaux, LuxembourgWageningen Food Safety Research (WFSR), Part of Wageningen University and Research, Wageningen, NetherlandsT3S, INSERM UMR-S 1124, Université Paris Cité, Paris, FranceDepartment of Food Safety, German Federal Institute for Risk Assessment, Berlin, GermanyDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Université degli Studi di Milano, Milan, ItalyFaculty of Pharmacy, University of Ljubljana, Ljubljana, SloveniaWageningen Food Safety Research (WFSR), Part of Wageningen University and Research, Wageningen, NetherlandsNorwegian Veterinary Institute, Oslo, NorwayFaculty of Pharmacy, University of Ljubljana, Ljubljana, SloveniaDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Université degli Studi di Milano, Milan, ItalyBiochemical Immunotoxicology Group, Institute of Medical Biochemistry, Medical University of Innsbruck, Innsbruck, Austria0Immune Endocrine Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, LuxembourgLuxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg1Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, HungaryWageningen Food Safety Research (WFSR), Part of Wageningen University and Research, Wageningen, Netherlands2Section for Occupational Toxicology, National Institute of Occupational Health, Oslo, NorwayDepartment of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway1Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, HungaryDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Université degli Studi di Milano, Milan, Italy2Section for Occupational Toxicology, National Institute of Occupational Health, Oslo, NorwayBiochemical Immunotoxicology Group, Institute of Medical Biochemistry, Medical University of Innsbruck, Innsbruck, Austria3Helmholtz Centre for Environmental Research, Leipzig, Germany4Innovative Testing in Life Sciences and Chemistry, Research Center for Healthy and Sustainable Living, University of Applied Sciences, Utrecht, Netherlands5IRAS-Toxicology, Population Health Sciences, Faculty of Veterinary Sciences, Utrecht University, Utrecht, Netherlands6Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge, Lisbon, PortugalNorwegian Veterinary Institute, Oslo, Norway7Centre for Health Protection, National Institute of Public Health and the Environment, Bilthoven, Netherlands2Section for Occupational Toxicology, National Institute of Occupational Health, Oslo, Norway1Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, Hungary0Immune Endocrine Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg7Centre for Health Protection, National Institute of Public Health and the Environment, Bilthoven, Netherlands3Helmholtz Centre for Environmental Research, Leipzig, GermanyT3S, INSERM UMR-S 1124, Université Paris Cité, Paris, FranceAs a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immunotoxicity of chemicals relies heavily on rodent models and a limited number of Organisation for Economic Co-operation and Development (OECD) test guidelines, which only capture a fraction of potential toxic properties. Due to this limitation, various authorities, including the World Health Organization and the European Food Safety Authority have highlighted the need for the development of novel approaches without the use of animals for immunotoxicity testing of chemicals. In this paper, we present a concise overview of ongoing efforts dedicated to developing and standardizing methodologies for a comprehensive characterization of the immunotoxic effects of chemicals, which are performed under the EU-funded Partnership for the Assessment of Risk from Chemicals (PARC).https://www.frontiersin.org/articles/10.3389/ftox.2024.1339104/fullPARCnew approach methodologiesNAMsimmunotoxicologyimmunosuppressionregulatory toxicology |
| spellingShingle | Igor Snapkow Nicola M. Smith Emma Arnesdotter Karsten Beekmann Etienne B. Blanc Albert Braeuning Emanuela Corsini Marija Sollner Dolenc Loes P. M. Duivenvoorde Gunnar Sundstøl Eriksen Nina Franko Valentina Galbiati Johanna M. Gostner Nathalie Grova Arno C. Gutleb Rita Hargitai Aafke W. F. Janssen Solveig A. Krapf Birgitte Lindeman Katalin Lumniczky Ambra Maddalon Steen Mollerup Lucia Parráková Arkadiusz Pierzchalski Raymond H. H. Pieters Raymond H. H. Pieters Maria J. Silva Anita Solhaug Yvonne C. M. Staal Anne Straumfors Tünde Szatmári Jonathan D. Turner Rob J. Vandebriel Ana Claudia Zenclussen Robert Barouki New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project Frontiers in Toxicology PARC new approach methodologies NAMs immunotoxicology immunosuppression regulatory toxicology |
| title | New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project |
| title_full | New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project |
| title_fullStr | New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project |
| title_full_unstemmed | New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project |
| title_short | New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project |
| title_sort | new approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals a parc partnership for the assessment of risk from chemicals project |
| topic | PARC new approach methodologies NAMs immunotoxicology immunosuppression regulatory toxicology |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2024.1339104/full |
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