Integration of datasets for individual prediction of DNA methylation-based biomarkers

Integration of datasets for individual prediction of DNA methylation-based biomarkers

Abstract Background Epigenetic scores (EpiScores) can provide biomarkers of lifestyle and disease risk. Projecting new datasets onto a reference panel is challenging due to separation of technical and biological variation with array data. Normalisation can standardise data distributions but may also...

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Bibliographic Details
Main Authors: Charlotte Merzbacher, Barry Ryan, Thibaut Goldsborough, Robert F. Hillary, Archie Campbell, Lee Murphy, Andrew M. McIntosh, David Liewald, Sarah E. Harris, Allan F. McRae, Simon R. Cox, Timothy I. Cannings, Catalina A. Vallejos, Daniel L. McCartney, Riccardo E. Marioni
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Genome Biology
Subjects:
DNA methylation
Prediction
Biomarker
Online Access:https://doi.org/10.1186/s13059-023-03114-5

Internet

https://doi.org/10.1186/s13059-023-03114-5

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