2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies

2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies

Abstract Background Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated extraordinary efficacy in B cell malignancy therapy and have been approved by the US Food and Drug Administration for diffuse large B cell lymphoma and acute B lymphocytic leukemia treatment. However, treatmen...

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Bibliographic Details
Main Authors: Yingxi Xu, Qian Liu, Mengjun Zhong, Zhenzhen Wang, Zhaoqi Chen, Yu Zhang, Haiyan Xing, Zheng Tian, Kejing Tang, Xiaolong Liao, Qing Rao, Min Wang, Jianxiang Wang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Hematology & Oncology
Subjects:
CD5
CAR
NK
Immunotherapy
T cell malignancies
Online Access:http://link.springer.com/article/10.1186/s13045-019-0732-7

Internet

http://link.springer.com/article/10.1186/s13045-019-0732-7

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