The Complex Effects of PKM2 and PKM2:IP<sub>3</sub>R Disruption on Intracellular Ca<sup>2+</sup> Handling and Cellular Functions

Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1,4,5-trisphosphate (IP<sub>3</sub>) receptor (IP<sub>3</sub>R) and suppress its activity. To further investigate the physiological importance of the PKM2:IP<sub>3</sub>R interaction, we develop...

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Bibliographic Details
Main Authors: Fernanda O. Lemos, Ian de Ridder, Martin D. Bootman, Geert Bultynck, Jan B. Parys
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/12/21/2527