Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice and humans.

Bibliographic Details
Main Authors: Cristina Llorente, Peter Jepsen, Tatsuo Inamine, Lirui Wang, Sena Bluemel, Hui J. Wang, Rohit Loomba, Jasmohan S. Bajaj, Mitchell L. Schubert, Masoumeh Sikaroodi, Patrick M. Gillevet, Jun Xu, Tatiana Kisseleva, Samuel B. Ho, Jessica DePew, Xin Du, Henrik T. Sørensen, Hendrik Vilstrup, Karen E. Nelson, David A. Brenner, Derrick E. Fouts, Bernd Schnabl
Format: Article
Language:English
Published: Nature Portfolio 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00796-x

Internet

https://doi.org/10.1038/s41467-017-00796-x

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