Analysis of Genotype-Phenotype Correlations in Patients With Degenerative Dementia Through the Whole Exome Sequencing

Analysis of Genotype-Phenotype Correlations in Patients With Degenerative Dementia Through the Whole Exome Sequencing

Background: Sporadic dementias generally occur in older age and are highly polygenic, which indicates some patients transmitted in a poly-genes hereditary fashion.Objective: Our study aimed to analyze the correlations of genetic features with clinical symptoms in patients with degenerative dementia....

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Bibliographic Details
Main Authors: Lin Sun, Jianye Zhang, Ning Su, Shaowei Zhang, Feng Yan, Xiang Lin, Jie Yu, Wei Li, Xia Li, Shifu Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
frontotemporal lobe degeneration
dementia
next-generation sequencing
whole exome sequencing (WES)
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.745407/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.745407/full

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