IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α.

IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α.

The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ-independent CD4 T cell based control of M. tuberculosis infection has been demonstrated in vivo it is unclear whether...

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Bibliographic Details
Main Authors: Erik Van Dis, Douglas M Fox, Huntly M Morrison, Daniel M Fines, Janet Peace Babirye, Lily H McCann, Sagar Rawal, Jeffery S Cox, Sarah A Stanley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010721

Internet

https://doi.org/10.1371/journal.ppat.1010721

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