Both common variations and rare non-synonymous substitutions and small insertion/deletions in <it>CLU </it>are associated with increased Alzheimer risk

Both common variations and rare non-synonymous substitutions and small insertion/deletions in <it>CLU </it>are associated with increased Alzheimer risk

<p>Abstract</p> <p>Background</p> <p>We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (<it>CLU) </it>with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all <it>CLU </it>c...

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Bibliographic Details
Main Authors: Bettens Karolien, Brouwers Nathalie, Engelborghs Sebastiaan, Lambert Jean-Charles, Rogaeva Ekaterina, Vandenberghe Rik, Le Bastard Nathalie, Pasquier Florence, Vermeulen Steven, Van Dongen Jasper, Mattheijssens Maria, Peeters Karin, Mayeux Richard, St George-Hyslop Peter, Amouyel Philippe, De Deyn Peter P, Sleegers Kristel, Van Broeckhoven Christine
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer disease
clusterin gene (<it>CLU</it>)
genomic resequencing
non-synonymous substitutions
insertions/deletions
β-chain domain
meta-analysis
Online Access:http://www.molecularneurodegeneration.com/content/7/1/3

Internet

http://www.molecularneurodegeneration.com/content/7/1/3

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