Heterologous Expression of the Antiviral Lectin Griffithsin in Probiotic <i>Saccharomyces boulardii</i> and In Vitro Characterization of Its Properties

Heterologous Expression of the Antiviral Lectin Griffithsin in Probiotic <i>Saccharomyces boulardii</i> and In Vitro Characterization of Its Properties

In this study, the probiotic yeast <i>Saccharomyces boulardii</i> was engineered to secrete the antiviral lectin griffithsin. Twelve genetic tools with the griffithsin gene were cloned into the vector pSF-TEF1-URA3 and introduced into <i>S. boulardii</i>. In the recombinant s...

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Bibliographic Details
Main Authors: Jie Tang, Ran Li, Tingyu Jiang, Jiachen Lv, Yuwei Jiang, Xingjian Zhou, Hong Chen, Meiliang Li, Aimin Wu, Bing Yu, Timo M. Takala, Per E. J. Saris, Shuhong Li, Zhengfeng Fang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Microorganisms
Subjects:
<i>Saccharomyces boulardii</i>
griffithsin
next-generation probiotics
antiviral
heterologous expression
Online Access:https://www.mdpi.com/2076-2607/12/12/2414

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https://www.mdpi.com/2076-2607/12/12/2414

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