Glycan Profile Analysis of Engineered Trastuzumab with Rationally Added Glycosylation Sequons Presents Significantly Increased Glycan Complexity

Protein aggregation constitutes a recurring complication in the manufacture and clinical use of therapeutic monoclonal antibodies (mAb) and mAb derivatives. Antibody aggregates can reduce production yield, cause immunogenic reactions, decrease the shelf-life of the pharmaceutical product and impair...

Full description

Bibliographic Details
Main Authors: Esteban Cruz, Vicki Sifniotis, Zeynep Sumer-Bayraktar, Mouhamad Reslan, Lorna Wilkinson-White, Stuart Cordwell, Veysel Kayser
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/13/11/1747