Discovery of physiological and cancer-related regulators of 3′ UTR processing with KAPAC

Discovery of physiological and cancer-related regulators of 3′ UTR processing with KAPAC

Abstract 3′ Untranslated regions (3' UTRs) length is regulated in relation to cellular state. To uncover key regulators of poly(A) site use in specific conditions, we have developed PAQR, a method for quantifying poly(A) site use from RNA sequencing data and KAPAC, an approach that infers activ...

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Bibliographic Details
Main Authors: Andreas J. Gruber, Ralf Schmidt, Souvik Ghosh, Georges Martin, Andreas R. Gruber, Erik van Nimwegen, Mihaela Zavolan
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Genome Biology
Subjects:
Cleavage and polyadenylation
APA
CFIm
KAPAC
PAQR
HNRNPC
Online Access:http://link.springer.com/article/10.1186/s13059-018-1415-3

Internet

http://link.springer.com/article/10.1186/s13059-018-1415-3

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