β-sitosterol inhibits trimethylamine production by regulating the gut microbiota and attenuates atherosclerosis in ApoE–/– mice

β-sitosterol inhibits trimethylamine production by regulating the gut microbiota and attenuates atherosclerosis in ApoE–/– mice

The intestinal microbial metabolite trimethylamine (TMA), which is activated by flavin monooxygenase (FMO) to produce trimethylamine-N-oxide (TMAO), has been implicated in the pathogenesis of atherosclerosis (AS), leading to the development of therapeutic strategies for AS. This study aimed to inves...

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Bibliographic Details
Main Authors: Weiping Wu, Wugao Liu, Huafu Wang, Wei Wang, Weihua Chu, Jing Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
β-sitosterol
gut microbiota
TMA
TMAO
atherosclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.986905/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.986905/full

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