Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
Abstract Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer metastasis, the mechanism by which histone methylation regulates metastasis has not been fully elucidated. Here, we found that the histone met...
Main Authors: | Kwangho Kim, Tae Young Ryu, Eunsun Jung, Tae-Su Han, Jinkwon Lee, Seon-Kyu Kim, Yu Na Roh, Moo-Seung Lee, Cho-Rok Jung, Jung Hwa Lim, Ryuji Hamamoto, Hye Won Lee, Keun Hur, Mi-Young Son, Dae-Soo Kim, Hyun-Soo Cho |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-05-01
|
Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-023-00987-1 |
Similar Items
-
Negative regulation of CDKN1A by the histone methyltransferase EHMT2 for cell growth in colorectal cancer
by: Kwangho Kim, et al.
Published: (2022-09-01) -
Advances of Histone Methyltransferase SMYD3 in Tumors
by: Shangwen DONG, et al.
Published: (2014-09-01) -
Structural and functional profiling of the human histone methyltransferase SMYD3.
by: Kenneth W Foreman, et al.
Published: (2011-01-01) -
The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells
by: Lianhua Piao, et al.
Published: (2014-03-01) -
Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model
by: Jamal B. Williams, et al.
Published: (2023-01-01)