Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice

Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice

Inflammation has been associated with depression, and innate immune receptors, such as the Toll-like receptor (TLR) 2/4 in the medial prefrontal cortex (mPFC), are crucial for chronic stress-induced depression-related behaviors in mice. HMGB1, a putative ligand for TLR2/4, has been suggested to prom...

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Bibliographic Details
Main Authors: Shiho Kitaoka, Ayaka Tomohiro, Shinya Ukeshima, Keyue Liu, Hidenori Wake, Shinya H. Kimura, Yasuhiko Yamamoto, Masahiro Nishibori, Tomoyuki Furuyashiki
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
repeated social defeat stress
depression
medial prefrontal cortex
HMGB1
RAGE
Online Access:https://www.mdpi.com/2073-4409/12/13/1789

Internet

https://www.mdpi.com/2073-4409/12/13/1789

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