Induction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background

Induction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background

In vivo induction of antigen (Ag)-specific regulatory T cells (Treg) is considered the holy grail of therapeutic strategies for restoring tolerance in autoimmunity. Unfortunately, in the autoimmune disease multiple sclerosis, an effective and durable therapy targeting the diverse repertoire of emerg...

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Bibliographic Details
Main Authors: Geoffrey D. Keeler, Cristina D. Gaddie, Addelynn S. Sagadevan, Kevin G. Senior, Isabelle Côté, Michaela Rechdan, Daniel Min, David Mahan, Bianca Poma, Brad E. Hoffman
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
immunotherapy
regulatory T cells
immune tolerance
Tregs
multiple sclerosis
autoimmune disease
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012200184X

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http://www.sciencedirect.com/science/article/pii/S232905012200184X

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