Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological symptoms of MDD. Zuranolone (SAGE-217), a neuroact...

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Bibliographic Details
Main Authors: Keiko Takasu, Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Koichi Ogawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuroactive steroid
benzodiazepine
extrasynaptic GABAA receptor
social defeat stress model
antidepressant-like effect
theta activity
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1274459/full

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https://www.frontiersin.org/articles/10.3389/fncel.2023.1274459/full

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