Akkermansia deficiency and mucin depletion are implicated in intestinal barrier dysfunction as earlier event in the development of inflammation in interleukin-10-deficient mice

Akkermansia deficiency and mucin depletion are implicated in intestinal barrier dysfunction as earlier event in the development of inflammation in interleukin-10-deficient mice

BackgroundDysbiosis and mucin depletion are related with intestinal barrier dysfunction and seems to be an early pathophysiological event in inflammatory bowel disease (IBD). The objective of this work is to study these parameters in the natural history of colitis in IL-10 deficient mice (IL-10−/−)....

Full description

Bibliographic Details
Main Authors: Beatriz López-Cauce, Marta Puerto, Juan José García, Manuel Ponce-Alonso, Federico Becerra-Aparicio, Rosa del Campo, Isabel Peligros, María J. Fernández-Aceñero, Yésica Gómez-Navarro, José M. Lara, José Miranda-Bautista, Ignacio Marín-Jiménez, Rafael Bañares, Luis Menchén
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
Akkermansia muciniphila
gut microbiome
mucin
intestinal barrier
interleukin-10-deficient mice
inflammatory bowel disease
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1083884/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1083884/full

Similar Items