Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

In the first meiotic cell division, proper segregation of chromosomes in most organisms depends on chiasmata, exchanges of continuity between homologous chromosomes that originate from the repair of programmed double-strand breaks (DSBs) catalyzed by the Spo11 endonuclease. Since DSBs can lead to ir...

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Bibliographic Details
Main Authors: Heyun Guo, Ericca L Stamper, Aya Sato-Carlton, Masa A Shimazoe, Xuan Li, Liangyu Zhang, Lewis Stevens, KC Jacky Tam, Abby F Dernburg, Peter M Carlton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
meiosis
double-strand breaks
phosphoregulation
ATR
PP4
Online Access:https://elifesciences.org/articles/77956

Internet

https://elifesciences.org/articles/77956

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