Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages

Abstract Background Solid tumors residing in tissues and organs leave footprints in circulation through circulating tumor cells (CTCs) and circulating tumor DNAs (ctDNA). Characterization of the ctDNA portraits and comparison with tumor DNA mutational portraits may reveal clinically actionable infor...

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Bibliographic Details
Main Authors: Meng Yang, Umit Topaloglu, W. Jeffrey Petty, Matthew Pagni, Kristie L. Foley, Stefan C. Grant, Mac Robinson, Rhonda L. Bitting, Alexandra Thomas, Angela T. Alistar, Rodwige J. Desnoyers, Michael Goodman, Carol Albright, Mercedes Porosnicu, Mihaela Vatca, Shadi A. Qasem, Barry DeYoung, Ville Kytola, Matti Nykter, Kexin Chen, Edward A. Levine, Edgar D. Staren, Ralph B. D’Agostino, Robin M. Petro, William Blackstock, Bayard L. Powell, Edward Abraham, Boris Pasche, Wei Zhang
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Hematology & Oncology
Subjects:
Liquid biopsy
Non-invasive
Clonality
Mutation rate
Lung cancer
Online Access:http://link.springer.com/article/10.1186/s13045-017-0468-1

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http://link.springer.com/article/10.1186/s13045-017-0468-1

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