Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis

Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis

Ulcerative colitis is an idiopathic disease that is widely incident worldwide. Canagliflozin, antidiabetic agent, exhibited significant anti-inflammatory effects in a variety of animal models. Additionally, hyaluronic acid is considered one of the key players in the tissue regeneration process. It h...

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Bibliographic Details
Main Authors: Mohamed Nasr, Simona Cavalu, Sameh Saber, Mahmoud E. Youssef, Amir Mohamed Abdelhamid, Heba I. Elagamy, Islam Kamal, Ahmed Gaafar Ahmed Gaafar, Eman El-Ahwany, Noha A. Amin, Samuel Girgis, Rawan El-Sandarosy, Fatma Mahmoud, Hadeer Rizk, Merna Mansour, Amal Hasaballah, Amira Abd El-Rafi, Reem Abd El-Azez, Mahy Essam, Dina Mohamed, Nada Essam, Osama A. Mohammed
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Canagliflozin
Chitosan
Hyaluronic acid
Microspheres
AMPK/NFκB/NLRP3 axis
Ulcerative colitis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222007983

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http://www.sciencedirect.com/science/article/pii/S0753332222007983

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