Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis
Ulcerative colitis is an idiopathic disease that is widely incident worldwide. Canagliflozin, antidiabetic agent, exhibited significant anti-inflammatory effects in a variety of animal models. Additionally, hyaluronic acid is considered one of the key players in the tissue regeneration process. It h...
Main Authors: | Mohamed Nasr, Simona Cavalu, Sameh Saber, Mahmoud E. Youssef, Amir Mohamed Abdelhamid, Heba I. Elagamy, Islam Kamal, Ahmed Gaafar Ahmed Gaafar, Eman El-Ahwany, Noha A. Amin, Samuel Girgis, Rawan El-Sandarosy, Fatma Mahmoud, Hadeer Rizk, Merna Mansour, Amal Hasaballah, Amira Abd El-Rafi, Reem Abd El-Azez, Mahy Essam, Dina Mohamed, Nada Essam, Osama A. Mohammed |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-09-01
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Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222007983 |
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