A new system for multiplexed mosaic analysis of gene function in the mouse
In a recent issue of Cell, Liu et al. present an innovative mouse model system in which Cre/lox stochastically turns on transgenic expression of one out of up to 100 sgRNAs in somatic cells, creating genetic mosaicism that enables the multiplexed assessment of gene function in vivo.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
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| Series: | Cell Reports: Methods |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667237522001771 |