Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans

Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans

IntroductionVascular dysfunction and chronic inflammation are characteristics of obesity-induced adipose tissue dysfunction. Proinflammatory cytokines can drive an endothelial-to-mesenchymal transition (EndoMT), where endothelial cells undergo a phenotypic switch to mesenchymal-like cells that are p...

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Bibliographic Details
Main Authors: Nicholas W. Chavkin, Tanvi Vippa, Changhee Jung, Stephanie McDonnell, Karen K. Hirschi, Noyan Gokce, Kenneth Walsh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
endothelial-to-mesenchymal transition
obesity
adipose
endothelium
aging
vascular biology
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1264479/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.1264479/full

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