Rapid detection of SNP (c.309T>G) in the MDM2 gene by the Duplex SmartAmp method.

Rapid detection of SNP (c.309T>G) in the MDM2 gene by the Duplex SmartAmp method.

Genetic polymorphisms in the human MDM2 gene are suggested to be a tumor susceptibility marker and a prognostic factor for cancer. It has been reported that a single nucleotide polymorphism (SNP) c.309T>G in the MDM2 gene attenuates the tumor suppressor activity of p53 and accelerates tumor forma...

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Bibliographic Details
Main Authors: Yasuaki Enokida, Kimihiro Shimizu, Jun Atsumi, Alexander Lezhava, Yuki Tanaka, Yasumasa Kimura, Takahiro Soma, Takeshi Hanami, Yuki Kawai, Kengo Usui, Yasuko Okano, Seiichi Kakegawa, Hiroomi Ogawa, Yohei Miyamae, Yohei Miyagi, Haruhiko Nakayama, Toshihisa Ishikawa, Yoshihide Hayashizaki, Izumi Takeyoshi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3614994?pdf=render

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http://europepmc.org/articles/PMC3614994?pdf=render

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