Enhancing HIF-1α–P2X2 signaling in dorsal raphe serotonergic neurons promotes psychological resilience

Enhancing HIF-1α–P2X2 signaling in dorsal raphe serotonergic neurons promotes psychological resilience

Major depressive disorder (MDD) is a devastating condition. Although progress has been made in the past seven decades, patients with MDD continue to receive an inadequate treatment, primarily due to the late onset of first-line antidepressant drugs and to their acute withdrawal symptoms. Resilience...

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Bibliographic Details
Main Authors: Yuan Zhang, Yi-da Pan, Wen-ying Zheng, Huan-yu Li, Min-zhen Zhu, Wen-jie Ou yang, Yu Qian, Gustavo Turecki, Naguib Mechawar, Xin-hong Zhu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Redox Biology
Subjects:
Intermittent hypobaric hypoxia training
Resilience
Hypoxia-inducible factor-1α
The dorsal raphe nucleus
P2X2 receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723004068

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http://www.sciencedirect.com/science/article/pii/S2213231723004068

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