Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function

Long-and middle-wavelength cone photoreceptors, which are responsible for our visual acuity and color vision, comprise ~95% of our total cone population and are concentrated in the fovea of our retina. Previously, we characterized the disease mechanisms of the L/M-cone opsin missense mutations N94K,...

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Bibliographic Details
Main Authors: Emily R. Sechrest, Robert J. Barbera, Xiaojie Ma, Frank Dyka, Junyeop Ahn, Brooke A. Brothers, Marion E. Cahill, Isaac Hall, Wolfgang Baehr, Wen-Tao Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1368089/full