Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease

Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease

Abstract In addition to protective “immune response”, sepsis is characterized by destructive “endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction. Complement activation generates membrane attack complex (MAC). MAC causes channel formation to the cell membrane...

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Bibliographic Details
Main Author: Jae C. Chang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Thrombosis Journal
Subjects:
Anti-microthrombotic therapy
C5b-9 (membrane attack complex [MAC])
Disseminated intravascular coagulation (“DIC”, ill-founded DIC)
Disseminated intravascular microthrombosis (DIT)
Endotheliopathy
Microthrombogenesis
Online Access:http://link.springer.com/article/10.1186/s12959-019-0198-4

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http://link.springer.com/article/10.1186/s12959-019-0198-4

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