Potent Inhibition of Macropinocytosis by Niclosamide in Cancer Cells: A Novel Mechanism for the Anticancer Efficacy for the Antihelminthic

Potent Inhibition of Macropinocytosis by Niclosamide in Cancer Cells: A Novel Mechanism for the Anticancer Efficacy for the Antihelminthic

Niclosamide, a drug used to treat tapeworm infection, possesses anticancer effects by interfering with multiple signaling pathways. Niclosamide also causes intracellular acidification. We have recently discovered that the amino acid transporter SLC38A5, an amino acid-dependent Na<sup>+</sup...

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Bibliographic Details
Main Authors: Souad R. Sennoune, Gunadharini Dharmalingam Nandagopal, Sabarish Ramachandran, Marilyn Mathew, Sathish Sivaprakasam, Valeria Jaramillo-Martinez, Yangzom D. Bhutia, Vadivel Ganapathy
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
niclosamide
macropinocytosis
Na<sup>+</sup>/H<sup>+</sup> exchanger
amino acid transporter
SLC38A5
amino acid-mediated Na<sup>+</sup>/H<sup>+</sup> exchange
Online Access:https://www.mdpi.com/2072-6694/15/3/759

Internet

https://www.mdpi.com/2072-6694/15/3/759

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