A hybrid machine learning framework for functional annotation of mitochondrial glutathione transport and metabolism proteins in cancers

A hybrid machine learning framework for functional annotation of mitochondrial glutathione transport and metabolism proteins in cancers

Abstract Background Alterations of metabolism, including changes in mitochondrial metabolism as well as glutathione (GSH) metabolism are a well appreciated hallmark of many cancers. Mitochondrial GSH (mGSH) transport is a poorly characterized aspect of GSH metabolism, which we investigate in the con...

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Bibliographic Details
Main Authors: Luke Kennedy, Jagdeep K. Sandhu, Mary-Ellen Harper, Miroslava Cuperlovic-Culf
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Bioinformatics
Subjects:
Mitochondria
Glutathione
Machine learning
Cancer
Protein function annotation
Transmembrane transport
Online Access:https://doi.org/10.1186/s12859-025-06051-1

Internet

https://doi.org/10.1186/s12859-025-06051-1

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