Interleukin (IL)-21 Promotes the Differentiation of IgA-Producing Plasma Cells in Porcine Peyer's Patches via the JAK-STAT Signaling Pathway

Interleukin (IL)-21 Promotes the Differentiation of IgA-Producing Plasma Cells in Porcine Peyer's Patches via the JAK-STAT Signaling Pathway

Secretory IgA is critical to prevent the invasion of pathogens via mucosa. However, the key factors and the mechanisms of IgA generation in the porcine gut are not well-understood. In this study, a panel of factors, including BAFF, APRIL, CD40L, TGF-β1, IL-6, IL-10, IL-17A, and IL-21, were employed...

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Bibliographic Details
Main Authors: Guo Liu, Bin Wang, Qingbo Chen, Yang Li, Baoyu Li, Ning Yang, Shanshan Yang, Shuxian Geng, Guangliang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
IL-21
IgA class switch recombination
B cell differentiation
JAK-STAT
porcine Peyer's patches
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01303/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01303/full

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