Rutaecarpine induces the differentiation of triple-negative breast cancer cells through inhibiting fumarate hydratase

Rutaecarpine induces the differentiation of triple-negative breast cancer cells through inhibiting fumarate hydratase

Abstract Background Triple-negative breast cancer (TNBC) is one of the most aggressive human cancers and has poor prognosis. Approximately 80% of TNBC cases belong to the molecular basal-like subtype, which can be exploited therapeutically by inducing differentiation. However, the strategies for ind...

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Bibliographic Details
Main Authors: Jie Lei, Yujia Pan, Rui Gao, Bin He, Zifeng Wang, Xinxing Lei, Zijian Zhang, Na Yang, Min Yan
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Translational Medicine
Subjects:
Rutaecarpine
Differentiation therapy
3D morphological screening
Online Access:https://doi.org/10.1186/s12967-023-04396-w

Internet

https://doi.org/10.1186/s12967-023-04396-w

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