Pharmacological Targeting of the RAGE-NFκB Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function

Pharmacological Targeting of the RAGE-NFκB Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function

Monocytes play a vital role in the development of cardiovascular diseases. Type 2 diabetes mellitus (T2DM) is a major CVD risk factor, and T2DM-induced aberrant activation and enhanced migration of monocytes is a vital pathomechanism that leads to atherogenesis. We recently reported the upregulation...

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Bibliographic Details
Main Authors: Marc Dorenkamp, Madina Nasiry, Dilvin Semo, Sybille Koch, Ivonne Löffler, Gunter Wolf, Holger Reinecke, Rinesh Godfrey
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
SHP-2
PTPN11
monocytes
NFκB
RAGE
methylglyoxal
Online Access:https://www.mdpi.com/2073-4409/12/3/513

Internet

https://www.mdpi.com/2073-4409/12/3/513

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