Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis

Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis

Abstract Introduction Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcome. In this study, we explored the impact of aging...

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Bibliographic Details
Main Authors: Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J. Dwivedi, Ji Zhou, Manoj M. Lalu, Asher A. Mendelson, Braedon McDonald, Colin A. Kretz, Alison E. Fox-Robichaud, Patricia C. Liaw
Format: Article
Language:English
Published: SpringerOpen 2024-03-01
Series:Intensive Care Medicine Experimental
Subjects:
Sepsis
Age
Fecal-induced peritonitis model
Immunothrombosis
National Preclinical Sepsis Platform
Online Access:https://doi.org/10.1186/s40635-024-00609-8

Internet

https://doi.org/10.1186/s40635-024-00609-8

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