Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis

The presence of islet cells double positive for insulin and glucagon (Ins<sup>+</sup>/Glu<sup>+</sup>) has been described in the pancreas from both type 2 (T2D) and type 1 (T1D) diabetic subjects. We studied the role of pro-inflammatory cytokines on the occurrence, trajectory...

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Bibliographic Details
Main Authors: Marta Tesi, Marco Bugliani, Gianmarco Ferri, Mara Suleiman, Carmela De Luca, Emanuele Bosi, Matilde Masini, Vincenzo De Tata, Conny Gysemans, Francesco Cardarelli, Miriam Cnop, Decio L. Eizirik, Piero Marchetti, Lorella Marselli
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomolecules
Subjects:
human islets
α-cells
β-cells
insulin
glucagon
diabetes
Online Access:https://www.mdpi.com/2218-273X/11/2/320

Internet

https://www.mdpi.com/2218-273X/11/2/320

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