Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors.

Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors.

The best characterized role for ubiquitination of membrane receptors is to negatively regulate signaling by targeting receptors for lysosomal degradation. The high affinity receptor for IgE (FcepsilonRI) expressed on mast cells and basophils is rapidly ubiquitinated upon antigen stimulation. However...

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Bibliographic Details
Main Authors: Rosa Molfetta, Francesca Gasparrini, Giovanna Peruzzi, Laura Vian, Mario Piccoli, Luigi Frati, Angela Santoni, Rossella Paolini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2680016?pdf=render

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http://europepmc.org/articles/PMC2680016?pdf=render

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