Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease

Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease

Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells. GFAP is neuroprotective, as knockout mice are hypersensitive to traumatic brain injury. GFAP in cerebrospinal f...

Full description

Bibliographic Details
Main Authors:	Akshatha Ganne, Meenakshisundaram Balasubramaniam, W. Sue T. Griffin, Robert J. Shmookler Reis, Srinivas Ayyadevara
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Pharmaceutics
Subjects:	glial fibrillary acidic protein (GFAP) protein aggregation protein phosphorylation post-translational modification (of proteins) Alzheimer’s disease (AD) biomarkers
Online Access:	https://www.mdpi.com/1999-4923/14/7/1354

Similar Items

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
by: Samuel Kakraba, et al.
Published: (2019-12-01)

A case of glial fibrillary acidotic protein (GFAP) meningoencephalitis with rheumatoid arthritis
by: Mehri Salari, et al.
Published: (2023-03-01)

Parainfectious Anti-Glial Fibrillary Acidic Protein-Associated Meningoencephalitis
by: Jae Young Joo, et al.
Published: (2022-01-01)

Case report: Headache as the sole neurological symptom in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy
by: Eslam Shosha, et al.
Published: (2024-04-01)

Autoimmune glial fibrillary acidic protein astrocytopathy associated with breast cancer: a case report
by: Tomonori Yaguchi, et al.
Published: (2023-04-01)

Control of the phosphorylation of the astrocyte marker glial fibrillary acidic protein (GFAP) in the immature rat hippocampus by glutamate and calcium ions: possible key factor in astrocytic plasticity
by: Rodnight R., et al.
Published: (1997-01-01)

Whether Serum Glial Fibrillary Acidic Protein (GFAP) Can Be Used as a Diagnostic Biomarker in Patients With Glioblastoma?
by: Charandeep Singh Gandhoke, et al.
Published: (2020-01-01)

LEVELS OF GLIAL FIBRILLARY ACIDIC PROTEIN IN SERUM AFTER CEREBRAL ISCHEMIA IN THE NEONATAL PERIOD
by: D. V. Blinov
Published: (2016-06-01)

Glial Fibrillary Acidic Protein sebagai Penanda Prognostik pada Stroke Iskemik Akut
by: Lisda Amalia
Published: (2023-10-01)

Magnetic Resonance Imaging Characteristics of Autoimmune Glial Fibrillary Acidic Protein (GFAP) Astrocytopathy: A Pediatric Series in Southwest China
by: Cheng W, et al.
Published: (2023-07-01)

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy in Children: A Retrospective Analysis of 35 Cases
by: Hongjun Fang, et al.
Published: (2021-11-01)

Clinical Features of Multicenter Autoimmune Glial Fibrillary Acidic Protein Astrocytosis
by: ZHENG Xiujun, et al.
Published: (2022-04-01)

Serum glial fibrillary acidic protein indicates memory impairment in patients with chronic heart failure
by: Jan Traub, et al.
Published: (2022-08-01)

Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure
by: Yu. P. Kovalchuk, et al.
Published: (2015-06-01)

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature
by: Fulan Shan, et al.
Published: (2018-12-01)

Clinical analysis and case series report on autoimmune glial fibrillary acidic protein astrocytopathy presenting with autonomic dysfunction
by: Xiao Ke Wu, et al.
Published: (2025-01-01)

Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brain
by: Minna A. Korolainen, et al.
Published: (2005-12-01)

Glial Fibrillary Acidic Protein in Blood as a Disease Biomarker of Neuromyelitis Optica Spectrum Disorders
by: Hyunjin Kim, et al.
Published: (2022-03-01)

Case report: Excessive daytime sleepiness as a presenting manifestation of autoimmune glial fibrillary acidic protein astrocytopathy
by: Mingyang Tang, et al.
Published: (2023-12-01)

Comparison of glial fibrillary acidic protein-immunoglobulin G-associated myelitis with myelin oligodendrocyte glycoprotein-immunoglobulin G-associated myelitis
by: Mengyang Sun, et al.
Published: (2023-10-01)

Glial fibrillary acidic protein astrocytopathy and tuberculous meningoencephalitis occurring in a patient with Legionella pneumonia: a case report
by: Ke Li, et al.
Published: (2023-02-01)

Anti⁃glial fibrillary acidic protein antibody positive recurrent short spinal segment myelitis: one case report
by: SUN Ya⁃ting, et al.
Published: (2022-09-01)

Cross‐sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease
by: Madeline Ally, et al.
Published: (2023-10-01)

Glial Fibrillary Acidic Protein Astrocytopathy in Pediatric Patients: A Retrospective Study
by: Haixia Huang, et al.
Published: (2021-01-01)

Evaluation of Blood Glial Fibrillary Acidic Protein as a Potential Marker in Huntington's Disease
by: Huajing You, et al.
Published: (2021-11-01)

Research progress of autoimmune glial fibrillary acidic protein astrocytopathy
by: WANG Wen⁃wen, et al.
Published: (2022-03-01)

Proteomic profiling of the brain from the <i>wobbler</i> mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein
by: Sandra Murphy, et al.
Published: (2023-08-01)

Case report: Autoimmune glial fibrillary acidic protein astrocytopathy with overlapping autoimmune syndrome
by: Wu-xiao Wei, et al.
Published: (2024-10-01)

Autoimmune glial fibrillary acidic protein astrocytopathy misdiagnosed as intracranial infectious diseases: case reports and literature review
by: Runhua Bai, et al.
Published: (2025-01-01)

A rare case of glial fibrillary acidic protein astrocytopathy that resolved spontaneously within a self-limited course
by: Mihiro Kaga, et al.
Published: (2023-10-01)

New tools for the visualization of glial fibrillary acidic protein in living cells
by: Ricardo Letra-Vilela, et al.
Published: (2020-01-01)

Overlapping Autoimmune Syndromes in Patients With Glial Fibrillary Acidic Protein Antibodies
by: Xinguang Yang, et al.
Published: (2018-04-01)

Autoimmune glial fibrillary acidic protein astrocytopathy with delayed abnormal magnetic resonance imaging findings
by: Shohei Imanaka, et al.
Published: (2022-06-01)

Glial fibrillary acidic protein as a serum neuromarker of brain injury in pediatric patients with congenital heart defects undergoing cardiac surgery
by: Chiperi Lacramioara-Eliza, et al.
Published: (2023-09-01)

Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia
by: Nuole Zhu, et al.
Published: (2021-12-01)

Prospective Validation of Glial Fibrillary Acidic Protein, d‐Dimer, and Clinical Scales for Acute Large‐Vessel Occlusion Ischemic Stroke Detection
by: Yasir Durrani, et al.
Published: (2024-07-01)

Glial Fibrillary Acidic Protein’s Usefulness as an Astrocyte Biomarker Using the Fully Automated LUMIPULSE<sup>®</sup> System
by: Jo Kamada, et al.
Published: (2024-11-01)

Autoimmune glial fibrillary acidic protein astrocytopathy masquerading as tuberculosis of the central nervous system: a case series
by: Amy ML Quek, et al.
Published: (2022-11-01)

The effect of glial fibrillary acidic protein expression on neurite outgrowth from retinal explants in a permissive environment
by: Toops Kimberly A, et al.
Published: (2012-12-01)

Blood Level of Glial Fibrillary Acidic Protein (GFAP) Does not Correlate With Disease Progression in a Rat Model of Familial ALS (SOD1G93A Transgenic)
by: Jeremy Jeffrey, et al.
Published: (2018-11-01)