Identification of giant Mimivirus protein functions using RNA interference

Identification of giant Mimivirus protein functions using RNA interference

Genomic analysis of giant viruses, such as Mimivirus, has revealed that more than half of the putative genes have no known functions (ORFans). We knocked down Mimivirus genes using short interfering RNA (siRNA) as a proof of concept to determine the functions of giant virus ORFans. As fibers are eas...

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Bibliographic Details
Main Authors: Haitham eSobhy, Bernard eLa Scola, Isabelle ePagnier, Didier eRaoult, Philippe eColson
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Microbiology
Subjects:
RNA Interference
Fiber
Mimivirus
giant virus
Megavirales
short interfering RNA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00345/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00345/full

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